← Back to the IWG Diagnosis Recommended Algorithm Interactive Clinical Tool · IWG 2021

Interactive Decision Tool

A step-by-step interpretation of amyloid and tau biomarkers in light of the clinical phenotype. Make your selections to see the diagnostic likelihood and the recommended further investigation.

1
Step 1 Phenotype
2
Step 2 Amyloid
3
Step 3 Tau
4
Result Diagnosis
Your selection
1

What is the patient's clinical phenotype?

Select the syndrome that best describes your patient's clinical presentation.

2

What is the amyloid biomarker status?

Based on CSF (Aβ42, Aβ40/Aβ42 ratio) or amyloid PET imaging.

3

What is the tau biomarker status?

Based on CSF (phospho-tau) or tau PET imaging.

Diagnostic likelihood
Recommended further investigation

Clinical context
View the full matrix →
Based on: Table 2 of Dubois B, Villain N, Frisoni GB, et al. Lancet Neurology, 2021 · ⬇ Download PDF · View on Lancet →